International Journal of Advanced Research in Computer and Communication Engineering publishes a paper "Optimized Design of Active Pixel Sensor using CMOS 180 nm Technology" by Dipti, Rajesh Mehra, and Deep Sehgal.
Contrary to the whole industry spending a lot of money on expensive device simulators, the authors simulate everything in SPICE:
The proposed timing sequence works well, just does not perform CDS and the small signals do not go through, not to talk about extra sensitivity to FD leakage:





