The five baby-faced guys, contestants on the British version of TV singing contest "The X Factor," beat Justin Bieber and Rihanna for best pop video, and fellow all-boy British outfit The Wanted as best new artists.
They also won the most-shareworthy video award for their debut hit single "What Makes You Beautiful" and later performed single "One Thing" to hordes of screaming girls at the two-hour Los Angeles ceremony.
"To win one Moonman is amazing, to win two is incredible," said Harry Styles, as the band collected the silver VMA trophy for best new artists.
One Direction, which is managed by British TV entrepreneur Simon Cowell, made history in March when it became the first UK group to see its first album, "Up All Night," debut at the top of the Billboard 200 chart.
For MTV VMAs Winner’s List, Click Here.