20 mad scientists who turned against their creations

At io9, Charlie Jane Anders came up with a list of twenty mad scientists who turned against their creations.One literary mad scientist on the list, which is dominated by movies and television shows:Marisa Coulter (His Dark Materials by Philip Pullman)Mrs. Coulter invents a method of controlling the "Dust" that attaches to people — unfortunately, this requires severing children from their Daemons,